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Search Results for " Mitochondrial Autophagy "

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51

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35

天然化合物

13

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2

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カタログ番号 製品名 別名 ターゲット
T1907 Mdivi-1 Mitochondrial division inhibitor 1 Apoptosis , Mitophagy , Dynamin , Autophagy
Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy.
T1554 Iohexol Mitophagy , Autophagy
Iohexol is a contrast agent. The osmolality of iohexol ranges from 322 mOsm/kg-approximately 1.1 times that of blood plasma-to 844 mOsm/kg, almost three times that of blood.
T0876 Clioquinol Chinoform,Iodochlorhydroxyquin Mitophagy , Antibiotic , Autophagy , Antifungal
Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.
T8526 Metformin 1,1-Dimethylbiguanide Mitophagy , AMPK , Autophagy
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm...
T2414 Torkinib PP 242 Apoptosis , Mitophagy , PI3K , mTOR , Autophagy
Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).
T0943 Carbamazepine NSC 169864 Mitophagy , Sodium Channel , Autophagy
Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysyna...
T6641 Rilmenidine Phosphate Apoptosis , Adrenergic Receptor , Autophagy , Imidazoline Receptor
Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.
T2099 ABT-737 Mitophagy , BCL , Autophagy
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).
T0972 Isoniazid INH,Isonicotinic acid hydrazide,Isonicotinic hydrazide Mitophagy , Dehydrogenase , CAT , Antibacterial , Autophagy
Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic.
T1567 Olanzapine LY170053 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR
Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
T8500 VLX600 OXPHOS , Mitochondrial Metabolism , Autophagy
VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.
T1829 Ruxolitinib INCB018424,(R)-Ruxolitinib Apoptosis , Mitophagy , Tyrosine Kinases , JAK , Autophagy
Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective. Rixolitinib exhibits antitumor activity and induces autophagy and apoptosis.
T2240 GSK2578215A Mitophagy , LRRK2 , Autophagy
GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
T0740 Metformin hydrochloride Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride Mitophagy , AMPK , Autophagy
Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including colon, pro...
T1583 Vorinostat MK0683,suberoylanilide hydroxamic acid,SAHA Apoptosis , Mitophagy , Virus Protease , HDAC , Autophagy
Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and i...
T8308 NL-1 Mitochondrial Metabolism , Autophagy
NL-1 is a mitoNEET inhibitor with antileukemic effect.
T13809 P62-mediated mitophagy inducer PMI Mitophagy
P62-mediated mitophagy inducer (PMI) is a regulator of mitophagy .
T1477 AICAR NSC105823,AICA Riboside,Acadesine,AICAR (Acadesine) Mitophagy , YAP , AMPK , Autophagy
AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
T0101 Doxazosin mesylate UK 33274 mesylate Mitophagy , Adrenergic Receptor , Autophagy
Doxazosin mesylate (UK 33274 mesylate)(UK 33274) is a quinazoline-derivative. It is a selectively antagonizes postsynaptic α1-adrenergic receptors.
T3015 Olaparib AZD2281,KU0059436 Mitophagy , PARP , Autophagy
Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and m...
T0374L Sunitinib SU 11248 Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy
Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM). Sunitinib has antitumor activity and can be used for the treatment of kidney cancer and ga...
T1634 Glibenclamide Glyburide Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T6223 U0126-EtOH U0126 Ethanol,U0126 Mitophagy , Influenza Virus , MEK , Autophagy
U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).
T6714 URB-597 KDS-4103,FAAH Inhibitor II Mitophagy , FAAH , Autophagy
URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
T9211 Mito-LND Mito-Loidamine OXPHOS , Reactive Oxygen Species , Mitochondrial Metabolism , Autophagy
Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
T2534 Pitavastatin calcium P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104 Apoptosis , Mitophagy , Endogenous Metabolite , HMG-CoA Reductase , Autophagy
Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cyt...
T1602 Valproic acid sodium salt Sodium Valproate Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , HDAC , Autophagy
Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha...
T0005 Aspirin Acetylsalicylate,Acetylsalicylic Acid,ASA Mitophagy , Virus Protease , COX , Autophagy
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel...
T0942 Quinacrine dihydrochloride Mepacrine dihydrochloride,SN-390,Quinacrine 2HCl Apoptosis , Mitophagy , DNA , Phospholipase , Parasite , Autophagy , Histamine Receptor
Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
T0947 Dexamethasone acetate Dexamethasone 21-acetate,Dexamethason acetate,NSC 39471 Glucocorticoid Receptor , Mitophagy , IL Receptor , Annexin A , NOS , Antibacterial , Autophagy
Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexa...
T1076 Dexamethasone MK 125,Prednisolone F,NSC 34521,Hexadecadrol Glucocorticoid Receptor , Mitophagy , IL Receptor , SARS-CoV , Antibacterial , Antibiotic , Autophagy , Complement System
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced...
T0374 Sunitinib Malate Sutent,SU 11248 (Malate),SU 11248,Sunitinib Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy
Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit.
T8929 BC1618 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Mitophagy , Others , E1/E2/E3 Enzyme , AMPK
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling. It promotes mitochondrial fission, promotes autophagy and imp...
T6474 Divalproex Sodium Valproate semisodium,Epival HDAC
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme...
T1764 Adezmapimod PB 203580,RWJ 64809,SB203580 Mitophagy , p38 MAPK , Autophagy
Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive. Adezmapimod possesses autophagy and mitochondrial autophagy activating activity. Adezmapimod displays more than 100...
T12352L Oxidopamine hydrobromide 6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide Mitophagy , Dopamine Receptor , Autophagy
Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.
T3043 Ruxolitinib phosphate INC424,INCB018424,INC 424 phosphate,Ruxolitinib (INCB-18424) phosphate,INCB018424 phosphate Mitophagy , JAK , Autophagy
Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.
T12352 Oxidopamine hydrochloride 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride Mitophagy , Dopamine Receptor , Autophagy
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.
T21332 U0126 U 0126,U-0126 Mitophagy , MEK , Autophagy
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhibits autophagy and mitophagy.
T13036 Sulfosuccinimidyl oleate Sulfo-N-succinimidyl oleate Mitophagy
Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibit...
T73331 GSK3-IN-3 Mitophagy , GSK-3
GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective...
T14346 Aumitin Others , Autophagy
Aumitin is a diaminopyrimidine-based autophagy inhibitor. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1], and it inhibits mitochondrial re...
T73599 TSPO ligand-1 Autophagy
TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.TSPO ligand-1 is an AUTAC4-binding protein in the transmembrane domain of the outer mitochondrial membrane, which induces mitochondrial autop...
T64755 Ammonium Chloride Autophagy , Antifungal
Ammonium chloride acts as a small molecule autophagy inhibitor.Ammonium chloride is a pH-regulating, heteropolar compound that can cause intracellular alkalosis and metabolic acidosis, thereby affecting enzyme activity a...
T83085 Anticancer agent 161
Compound 3b, known as Anticancer Agent 161, is a bioactive alkynol exhibiting potential anticancer properties. It has the capability to induce autophagy and deplete mitochondrial membrane potential [1].
T74571 TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1, comprising a translocator protein (TSPO) ligand and a linker, is instrumental in synthesizing mitochondria-targeting autophagy-targeting chimera (AUTAC). This compound binds TSPO on the o...
T21911 Rilmenidine hemifumarate Rilmenidine (hemifumarate),S-3341 hemifumarate Apoptosis , Imidazoline Receptor
Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulate...
T60356 Stavudine sodium
Stavudine sodium (d4T), an orally active nucleoside reverse transcriptase inhibitor (NRTI), demonstrates activity against both HIV-1 and HIV-2. It also inhibits mitochondrial DNA (mtDNA) replication, reduces NLRP3 inflam...
T36882 CAY10773
CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HC...
T79557 Fac-[Re(CO)3(L6)(H2O)][NO3] Apoptosis
Compound 6, fac-[Re(CO)3(L6)(H2O)][NO3], a rhenium(I) tricarbonyl aqua complex, serves as an anticancer agent by disrupting mitochondrial function. It exhibits cytotoxicity against prostate cancer cells with an IC50 of 5...

Compounds

Mdivi-1
T1907
Synonym: Mitochondrial division inhibitor 1
Target: Apoptosis, Mitophagy, Dynamin, Autophagy
Iohexol
T1554
Synonym:
Target: Mitophagy, Autophagy
Clioquinol
T0876
Synonym: Chinoform,Iodochlorhydroxyquin
Target: Mitophagy, Antibiotic, Autophagy, Antifungal
Metformin
T8526
Synonym: 1,1-Dimethylbiguanide
Target: Mitophagy, AMPK, Autophagy
Torkinib
T2414
Synonym: PP 242
Target: Apoptosis, Mitophagy, PI3K, mTOR, Autophagy
Carbamazepine
T0943
Synonym: NSC 169864
Target: Mitophagy, Sodium Channel, Autophagy
Rilmenidine Phosphate
T6641
Synonym:
Target: Apoptosis, Adrenergic Receptor, Autophagy, Imidazoline Receptor
ABT-737
T2099
Synonym:
Target: Mitophagy, BCL, Autophagy
Isoniazid
T0972
Synonym: INH,Isonicotinic acid hydrazide,Isonicotinic hydrazide
Target: Mitophagy, Dehydrogenase, CAT, Antibacterial, Autophagy
Olanzapine
T1567
Synonym: LY170053
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR
VLX600
T8500
Synonym:
Target: OXPHOS, Mitochondrial Metabolism, Autophagy
Ruxolitinib
T1829
Synonym: INCB018424,(R)-Ruxolitinib
Target: Apoptosis, Mitophagy, Tyrosine Kinases, JAK, Autophagy
GSK2578215A
T2240
Synonym:
Target: Mitophagy, LRRK2, Autophagy
Metformin hydrochloride
T0740
Synonym: Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride
Target: Mitophagy, AMPK, Autophagy
Vorinostat
T1583
Synonym: MK0683,suberoylanilide hydroxamic acid,SAHA
Target: Apoptosis, Mitophagy, Virus Protease, HDAC, Autophagy
NL-1
T8308
Synonym:
Target: Mitochondrial Metabolism, Autophagy
P62-mediated mitophagy inducer
T13809
Synonym: PMI
Target: Mitophagy
AICAR
T1477
Synonym: NSC105823,AICA Riboside,Acadesine,AICAR (Acadesine)
Target: Mitophagy, YAP, AMPK, Autophagy
Doxazosin mesylate
T0101
Synonym: UK 33274 mesylate
Target: Mitophagy, Adrenergic Receptor, Autophagy
Olaparib
T3015
Synonym: AZD2281,KU0059436
Target: Mitophagy, PARP, Autophagy
Sunitinib
T0374L
Synonym: SU 11248
Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy
Glibenclamide
T1634
Synonym: Glyburide
Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy
U0126-EtOH
T6223
Synonym: U0126 Ethanol,U0126
Target: Mitophagy, Influenza Virus, MEK, Autophagy
URB-597
T6714
Synonym: KDS-4103,FAAH Inhibitor II
Target: Mitophagy, FAAH, Autophagy
Mito-LND
T9211
Synonym: Mito-Loidamine
Target: OXPHOS, Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy
Pitavastatin calcium
T2534
Synonym: P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104
Target: Apoptosis, Mitophagy, Endogenous Metabolite, HMG-CoA Reductase, Autophagy
Valproic acid sodium salt
T1602
Synonym: Sodium Valproate
Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, HDAC, Autophagy
Aspirin
T0005
Synonym: Acetylsalicylate,Acetylsalicylic Acid,ASA
Target: Mitophagy, Virus Protease, COX, Autophagy
Quinacrine dihydrochloride
T0942
Synonym: Mepacrine dihydrochloride,SN-390,Quinacrine 2HCl
Target: Apoptosis, Mitophagy, DNA, Phospholipase, Parasite, Autophagy, Histamine Receptor
Dexamethasone acetate
T0947
Synonym: Dexamethasone 21-acetate,Dexamethason acetate,NSC 39471
Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, Annexin A, NOS, Antibacterial, Autophagy
Dexamethasone
T1076
Synonym: MK 125,Prednisolone F,NSC 34521,Hexadecadrol
Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, SARS-CoV, Antibacterial, Antibiotic, Autophagy, Complement System
Sunitinib Malate
T0374
Synonym: Sutent,SU 11248 (Malate),SU 11248,Sunitinib
Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy
BC1618
T8929
Synonym: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
Target: Mitophagy, Others, E1/E2/E3 Enzyme, AMPK
Divalproex Sodium
T6474
Synonym: Valproate semisodium,Epival
Target: HDAC
Adezmapimod
T1764
Synonym: PB 203580,RWJ 64809,SB203580
Target: Mitophagy, p38 MAPK, Autophagy
Oxidopamine hydrobromide
T12352L
Synonym: 6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide
Target: Mitophagy, Dopamine Receptor, Autophagy
Ruxolitinib phosphate
T3043
Synonym: INC424,INCB018424,INC 424 phosphate,Ruxolitinib (INCB-18424) phosphate,INCB018424 phosphate
Target: Mitophagy, JAK, Autophagy
Oxidopamine hydrochloride
T12352
Synonym: 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride
Target: Mitophagy, Dopamine Receptor, Autophagy
U0126
T21332
Synonym: U 0126,U-0126
Target: Mitophagy, MEK, Autophagy
Sulfosuccinimidyl oleate
T13036
Synonym: Sulfo-N-succinimidyl oleate
Target: Mitophagy
GSK3-IN-3
T73331
Synonym:
Target: Mitophagy, GSK-3
Aumitin
T14346
Synonym:
Target: Others, Autophagy
TSPO ligand-1
T73599
Synonym:
Target: Autophagy
Ammonium Chloride
T64755
Synonym:
Target: Autophagy, Antifungal
Anticancer agent 161
T83085
Synonym:
Target:
TSPO Ligand-Linker Conjugates 1
T74571
Synonym:
Target:
Rilmenidine hemifumarate
T21911
Synonym: Rilmenidine (hemifumarate),S-3341 hemifumarate
Target: Apoptosis, Imidazoline Receptor
Stavudine sodium
T60356
Synonym:
Target:
CAY10773
T36882
Synonym:
Target:
fac-[Re(CO)3(L6)(H2O)][NO3]
T79557
Synonym:
Target: Apoptosis
1 2
カタログ番号 製品名 別名 ターゲット
T5S1099 Liensinine Apoptosis , Mitophagy , Others , Autophagy
1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.
T6468 D-glutamine Mitophagy , Ferroptosis , Endogenous Metabolite , GluR , Autophagy
D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
T0595 Naringin Naringoside Mitophagy , P450 , Endogenous Metabolite , Autophagy
Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.
T3427 Polydatin Piceid,Polydotin Peceid Apoptosis , Mitophagy , NF-κB , Autophagy
Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...
T5515 Hemin Hemin chloride Mitophagy , Ferroptosis , Autophagy
Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme deficiency in patients, thereby inhibiting δ-aminolevulini...
T2174 Quercetin Sophoretin Apoptosis , Mitophagy , Reactive Oxygen Species , PI3K , Autophagy
Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5.4 μM). Quercetin can induce apoptosis and autophagy.
T2140 Parthenolide (-)-Parthenolide Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
T3028 Tripterin Celastrol,Tripterine Apoptosis , Mitophagy , Proteasome , Autophagy
Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodula...
T0649 Salicylic acid 2-Hydroxybenzoic acid Apoptosis , Mitophagy , COX , Endogenous Metabolite , Autophagy
Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
T2177 Kaempferol Kempferol,Robigenin Apoptosis , Estrogen Receptor/ERR , Mitophagy , Estrogen/progestogen Receptor , HIV Protease , Endogenous Metabolite , Parasite , Autophagy
Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
T4S1102 Liensinine diperchlorate Liensinine-Perchlorate Mitophagy , Others , Autophagy
Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome-lysosome fusion and exhibits biological activities such as...
T6062 Brefeldin A BFA,Ascotoxin,Cyanein,Decumbin ATPase , Mitophagy , Antibiotic , Autophagy , HSV , CRISPR/Cas9
Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activ...
T1659 Melatonin Melatonine,N-Acetyl-5-methoxytryptamine CaMK , Apoptosis , Mitophagy , Estrogen/progestogen Receptor , Melatonin Receptor , Glutathione Peroxidase , Endogenous Metabolite , ROR , Autophagy
Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin...
T2970 Rotenone Rotenon,Paraderil,Barbasco,Rotocide,Dactinol Apoptosis , Dehydrogenase , Mitochondrial Metabolism , p53 , Autophagy
Rotenone (Rotocide) is a natural product and a botanical insecticide. Rotenone is a mitochondrial electron transport complex I inhibitor that promotes the production of reactive oxygen species in mitochondria and induces...
T1879 3-Methyladenine 3-MA,NSC 66389 Mitophagy , PI3K , Endogenous Metabolite , Autophagy
3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM). 3-Methyladenine inhibits autophagy.
T1131 Ivermectin MK-933 Mitophagy , GluCls , P2X Receptor , SARS-CoV , HIV Protease , Antibiotic , Parasite , Autophagy , HSV
Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T1558 Resveratrol trans-Resveratrol,SRT 501 Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop...
TN1362 Afzelin Kaempferol-3-O-rhamnoside PTEN , p38 MAPK , TNF , Mitochondrial Metabolism , Antibacterial , Prostaglandin Receptor , Autophagy
Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced d...
T0687 Simvastatin MK-0733,MK 733 Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy
Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc...
T0132 Etoposide VP-16,VP-16-213 Apoptosis , Mitophagy , Topoisomerase , Antibacterial , Antibiotic , Autophagy
Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.
T1516 Curcumin Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant...
T3898 Schaftoside APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside Dynamin , Antioxidant , TLR , MyD88 , Mitochondrial Metabolism , Autophagy
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
T2830 Betulinic acid ALS-357,Lupatic acid,Betulic acid Apoptosis , Mitophagy , NF-κB , HIV Protease , Topoisomerase , Endogenous Metabolite , Aminopeptidase , Autophagy
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory propert...
T2870 Matrine Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
T5684 Ethyl 3,4-dihydroxybenzoate Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T6290 Tanespimycin 17-AAG,CP 127374,NSC 330507,KOS 953 Apoptosis , Mitophagy , HSP , Antibacterial , Antibiotic , Autophagy
Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T2822 Ginsenoside Rb1 Gypenoside Ⅲ,Gypenoside III ATPase , Mitophagy , IRAK , NF-κB , Autophagy , HSV
Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
T1020 Doxorubicin hydrochloride Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,NSC 123127 Apoptosis , Mitophagy , HBV , HIV Protease , Topoisomerase , Antibacterial , Antibiotic , AMPK , Autophagy
Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitum...
T1662 5-Aminolevulinic acid hydrochloride Hydrangin,5-ALA,5-Aminolevulinic acid HCl,ALA hydrochloride Apoptosis , Mitophagy , Endogenous Metabolite , Autophagy
5-Aminolevulinic acid hydrochloride (5-ALA) serves as an intermediate in the body's heme biosynthesis and is the universal precursor of tetrapyrroles.
T7064 Valproic Acid Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
T1456 Doxorubicin Hydroxydaunorubicin,Adriamycin Topoisomerase , AMPK
T4672 Brevilin A Apoptosis , Anti-infection , JAK , STAT , Autophagy
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...
TN6547 Angustifoline
Angustifoline has activity against gram-positive bacteria. It inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stim...
T73068 Mammea A/BA
Mammea A/BA demonstrates significant efficacy in inhibiting Trypanosoma cruzi (T. cruzi), through mechanisms such as mitochondrial dysfunction, increased production of reactive oxygen species (ROS), and DNA fragmentation...
T36489 Malformin A
Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhib...

天然物製品

Liensinine
T5S1099
Synonym:
Target: Apoptosis, Mitophagy, Others, Autophagy
D-glutamine
T6468
Synonym:
Target: Mitophagy, Ferroptosis, Endogenous Metabolite, GluR, Autophagy
Naringin
T0595
Synonym: Naringoside
Target: Mitophagy, P450, Endogenous Metabolite, Autophagy
Polydatin
T3427
Synonym: Piceid,Polydotin Peceid
Target: Apoptosis, Mitophagy, NF-κB, Autophagy
Hemin
T5515
Synonym: Hemin chloride
Target: Mitophagy, Ferroptosis, Autophagy
Quercetin
T2174
Synonym: Sophoretin
Target: Apoptosis, Mitophagy, Reactive Oxygen Species, PI3K, Autophagy
Parthenolide
T2140
Synonym: (-)-Parthenolide
Target: Apoptosis, Mitophagy, NF-κB, HDAC, Autophagy
Tripterin
T3028
Synonym: Celastrol,Tripterine
Target: Apoptosis, Mitophagy, Proteasome, Autophagy
Salicylic acid
T0649
Synonym: 2-Hydroxybenzoic acid
Target: Apoptosis, Mitophagy, COX, Endogenous Metabolite, Autophagy
Kaempferol
T2177
Synonym: Kempferol,Robigenin
Target: Apoptosis, Estrogen Receptor/ERR, Mitophagy, Estrogen/progestogen Receptor, HIV Protease, Endogenous Metabolite, Parasite, Autophagy
Liensinine diperchlorate
T4S1102
Synonym: Liensinine-Perchlorate
Target: Mitophagy, Others, Autophagy
Brefeldin A
T6062
Synonym: BFA,Ascotoxin,Cyanein,Decumbin
Target: ATPase, Mitophagy, Antibiotic, Autophagy, HSV, CRISPR/Cas9
Melatonin
T1659
Synonym: Melatonine,N-Acetyl-5-methoxytryptamine
Target: CaMK, Apoptosis, Mitophagy, Estrogen/progestogen Receptor, Melatonin Receptor, Glutathione Peroxidase, Endogenous Metabolite, ROR, Autophagy
Rotenone
T2970
Synonym: Rotenon,Paraderil,Barbasco,Rotocide,Dactinol
Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism, p53, Autophagy
3-Methyladenine
T1879
Synonym: 3-MA,NSC 66389
Target: Mitophagy, PI3K, Endogenous Metabolite, Autophagy
Ivermectin
T1131
Synonym: MK-933
Target: Mitophagy, GluCls, P2X Receptor, SARS-CoV, HIV Protease, Antibiotic, Parasite, Autophagy, HSV
Resveratrol
T1558
Synonym: trans-Resveratrol,SRT 501
Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal
Afzelin
TN1362
Synonym: Kaempferol-3-O-rhamnoside
Target: PTEN, p38 MAPK, TNF, Mitochondrial Metabolism, Antibacterial, Prostaglandin Receptor, Autophagy
Simvastatin
T0687
Synonym: MK-0733,MK 733
Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy
Etoposide
T0132
Synonym: VP-16,VP-16-213
Target: Apoptosis, Mitophagy, Topoisomerase, Antibacterial, Antibiotic, Autophagy
Curcumin
T1516
Synonym: Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow
Target: Mitophagy, Epigenetic Reader Domain, Ferroptosis, Influenza Virus, Nrf2, Histone Acetyltransferase, HDAC, Autophagy
Schaftoside
T3898
Synonym: APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside
Target: Dynamin, Antioxidant, TLR, MyD88, Mitochondrial Metabolism, Autophagy
Betulinic acid
T2830
Synonym: ALS-357,Lupatic acid,Betulic acid
Target: Apoptosis, Mitophagy, NF-κB, HIV Protease, Topoisomerase, Endogenous Metabolite, Aminopeptidase, Autophagy
Matrine
T2870
Synonym: Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine
Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy
Ethyl 3,4-dihydroxybenzoate
T5684
Synonym:
Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy
Tanespimycin
T6290
Synonym: 17-AAG,CP 127374,NSC 330507,KOS 953
Target: Apoptosis, Mitophagy, HSP, Antibacterial, Antibiotic, Autophagy
Ginsenoside Rb1
T2822
Synonym: Gypenoside Ⅲ,Gypenoside III
Target: ATPase, Mitophagy, IRAK, NF-κB, Autophagy, HSV
Doxorubicin hydrochloride
T1020
Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,NSC 123127
Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy
5-Aminolevulinic acid hydrochloride
T1662
Synonym: Hydrangin,5-ALA,5-Aminolevulinic acid HCl,ALA hydrochloride
Target: Apoptosis, Mitophagy, Endogenous Metabolite, Autophagy
Valproic Acid
T7064
Synonym: Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid
Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, Sodium Channel, HDAC, Autophagy
Doxorubicin
T1456
Synonym: Hydroxydaunorubicin,Adriamycin
Target: Topoisomerase, AMPK
Brevilin A
T4672
Synonym:
Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy
Angustifoline
TN6547
Synonym:
Target:
Mammea A/BA
T73068
Synonym:
Target:
Malformin A
T36489
Synonym:
Target:

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPJ-01354 ATG3 Protein, Human, Recombinant Human E. coli
Ubiquitin-like-conjugating enzyme ATG3 (ATG3), also known as Apg3L and Apg3p, functions as a regulatory component of autophagosome biogenesis necessary for autophagy. ATG3 exhibits 98% aa sequence identity with both its ...
TMPH-03245 BCL2 Protein, Rat, Recombinant (His) Rat in vitro E. coli expression system
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a fee...
TMPH-02520 BCL2 Protein, Mouse, Recombinant (His) Mouse E. coli
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a fee...
TMPH-00289 NOD2 Protein, Bovine, Recombinant (His & KSI) Bovine E. coli
Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, ...
TMPH-00340 ATG1 Protein, Candida glabrata, Recombinant (His) Candida glabrata E. coli
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein ...
TMPH-01004 Beclin-1 Protein, Human, Recombinant (His) Human E. coli
Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane traffickin...
TMPH-02538 Beclin-1 Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways...
TMPH-01262 PRKN Protein, Human, Recombinant (His & Myc) Human Baculovirus
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-01263 PRKN Protein, Human, Recombinant (His & SUMO) Human E. coli
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-02631 PRKN Protein, Mouse, Recombinant (GST) Mouse E. coli
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-03281 PRKN Protein, Rat, Recombinant (His & Myc) Rat Baculovirus
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-02479 PRKAA1 Protein, Mouse, Recombinant (E. coli, His) Mouse E. coli
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
TMPH-02478 PRKAA1 Protein, Mouse, Recombinant (His) Mouse Baculovirus
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
カタログ番号 製品名
L1120 AMPK-Targeted Compound Library

80 compounds
80 well-chosen unique AMPK-targeted small molecules;
L2550 Glutamine Metabolism Compound Library

565 compounds
A unique collection of 565 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ...